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KMID : 0376219840210010053
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Chonnam Medical Journal
1984 Volume.21 No. 1 p.53 ~ p.60
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Evaluation of Creatine Phosphokinase-BB in Acute Head Injury
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Abstract
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The total creatine phosphokinase(CPK) and it´s isoenzyme activities of serum were measured serially in 46 cases of acute head injury. Increased total CPK activities persisted until 7 days after trauma, on the other hand CPK-BB was detected early after trauma and disappeared within 48 hours in the most cases. And CPK-BB activities were higher in the earlier samplings.
CPK-BB acivities were detected in the serum of 32 out of 46 cases(70%) with the acute head injury. CPK-BB activity appeared more frequently in the severer injuries: in 45% of mild injuries, 67% of moderate injuries and 80% of severe injuries. The detection of CPK-BB occurred frequently in the cases with CT findings indicative of the severe brain damage or brain edema.
CPK-BB max activities correlated significantly with the degree of the head injury: 4.9U/e, 12.5U/e and 31-5U/e in mild, moderate and severe head injury in order. There was a highly significant correlation between CPK-BBmax and outcome, but a low CPK-BB activity was not necessarily a good prognostic sign. 61.5 io of patients who had a good outcome had a CPK-BBmax of less than 10U/e. 85.5% of those with a poor outcome had a CPK-BBmax of 10U/e or more (X2=8.3: p<0.01).
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